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Unravelling the Complexity of Colorectal Cancer: Heterogeneity, Clonal Evolution, and Clinical Implications by Nadia Saoudi González; Francesc Salvà; Javier Ros; Iosune Baraibar; Marta Rodríguez-Castells; Ariadna García; Adriana Alcaráz; Sharela Vega; Sergio Bueno; Josep Tabernero; Elena Elez is a Medicine article available to read on EtoBox.

What is Unravelling the Complexity of Colorectal Cancer: Heterogeneity, Clonal Evolution, and Clinical Implications about?

## Simple Summary Metastatic colorectal cancer is a complex, prevalent, and life-threatening disease influenced by various factors that affect its progression, evolution, and treatment responses. Tumor heterogeneity, stemming from genetic and non-genetic factors, impacts tumor development and therapy effectiveness. This feature can be assessed by computational analysis of next-generation sequencing to understand spatial tumor evolution and diversity. Analyzing circulating tumor DNA allows the study of temporal heterogeneity by real-time monitoring of tumor changes and treatment response. Different models explain the origins of this heterogeneity, emphasizing complex molecular pathways. This review examines these concepts and focuses on the clinical implications of clonal evolution and tumor heterogeneity. ## Abstract Colorectal cancer (CRC) is a global health concern and a leading cause of death worldwide. The disease’s course and response to treatment are significantly influenced by its heterogeneity, both within a single lesion and between primary and metastatic sites. Biomarkers, such as mutations in __KRAS__, __NRAS__, and __BRAF__, provide valuable guidance for treatment decis

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Author

Nadia Saoudi González; Francesc Salvà; Javier Ros; Iosune Baraibar; Marta Rodríguez-Castells; Ariadna García; Adriana Alcaráz; Sharela Vega; Sergio Bueno; Josep Tabernero; Elena Elez

Publisher

MDPI AG

Published

2023

Field

Medicine (Health Sciences)