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Autologous Stem-Cell Transplantation Outcomes for Relapsed Metastatic Germ-Cell Tumors in the Modern Era by Anis A. Hamid; Sarah C. Markt; Cécile Vicier; Kathleen McDermott; Paul Richardson; Vincent T. Ho; Christopher J. Sweeney is a Medicine article available to read on EtoBox.

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## Background: High-dose chemotherapy (hdct) with autologous stem-cell transplantation (asct) has been a standard therapy for relapsed metastatic germ-cell tumors (gcts) over the last 2 decades, but there have been many changes in practice over time with respect to stem-cell source, mobilization, and conditioning regimens. mobilization is impaired with greater cisplatin exposure. ## Patients and methods: Patients with relapsed gct who received hdct/asct at dana-farber cancer institute between 1997 and 2017 were identified. diagnosis, first-line chemotherapy, stem-cell mobilization, hdct, toxicity, and survival outcomes were annotated and descriptively summarized. univariable associations of clinicopathologic features and relapse and survival were assessed. time-to-event analyses were performed by hdct type and duration. ## Results: Thirty-five eligible patients were identified. the most common regimen before hdct was paclitaxel, ifosfamide, and cisplatin, and it resulted in a high rate of successful initial mobilization (95%). ten patients (29%) were mobilized with filgrastim and plerixafor (cxcr4 antagonist). all plerixafor-treated patients were mobilized with sufficient cells for

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Author

Anis A. Hamid; Sarah C. Markt; Cécile Vicier; Kathleen McDermott; Paul Richardson; Vincent T. Ho; Christopher J. Sweeney

Publisher

CIG Media Group, LP.; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 1558-7673)

Published

2018

Language

EN

Field

Medicine (Health Sciences)