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This study presents the development of αvβ3 integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles (LPHNPs) for the targeted co-delivery of paclitaxel (PTX) and tamoxifen (TMF) to treat triple-negative breast cancer (TNBC). The targeted LPHNPs demonstrated significantly higher drug uptake and apoptosis induction in TNBC cells compared to non-targeted nanoparticles and free drugs. The results indicate that the combination of PTX and TMF delivered via these targeted nanoparticles has

Author

shrutinarkhede24

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EN