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Autoantibody-induced Intestinal Inflammation and Weight Loss in Experimental Epidermolysis Bullosa Acquisita by Norito Ishii; Andreas Recke; Sidonia Mihai; Misa Hirose; Takashi Hashimoto; Detlef Zillikens; Ralf J Ludwig is a Medicine article available to read on EtoBox.

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## Abstract Type VII collagen (COL7) is a major constituent of the cutaneous basement membrane. Loss of tolerance to COL7 leads to the blistering skin disease epidermolysis bullosa acquisita (EBA). Antibodies to COL7 have also been detected in patients with inflammatory bowel disease (IBD), yet reports on the expression of COL7 in the gut are controversial and a pathogenic relevance of anti‐COL7 autoantibodies in IBD has not been demonstrated. We therefore characterized the expression patterns of COL7 in murine gastrointestinal organs and investigated if anti‐COL7 antibodies induce an inflammatory response in the gut. COL7 expression was analysed on the mRNA and protein levels. Mice were injected with rabbit anti‐murine COL7 IgG (passive EBA) or immunized with a fragment of murine COL7 (active EBA). COL7 was found to be expressed in buccal mucosa, oesophagus, stomach, small intestine, and colon. In addition to skin blistering, in both passive and active EBA, autoantibodies bound to the gastrointestinal basement membrane, fixed complement, and led to recruitment of leukocytes. Furthermore, blister formation was observed in the oesophagus (40%/38% of mice in passive/active model), st

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Author

Norito Ishii; Andreas Recke; Sidonia Mihai; Misa Hirose; Takashi Hashimoto; Detlef Zillikens; Ralf J Ludwig

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2011

Language

EN

Field

Medicine (Health Sciences)