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This document summarizes research on how the transcription factor COUP-TFI controls the differentiation of corticospinal motor neurons (CSMN) in a temporally and spatially specific manner during cortical development. The researchers found that loss of COUP-TFI function in somatosensory cortex causes premature generation of CSMN features and projections normally only found in motor cortex. This results in impaired motor function in adult mice. COUP-TFI is therefore critical for restricting CSMN differentiati

Author

Frontiers

Language

EN