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Effect of CYP2C9 , PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen by Dmitry A. Sychev; Tatiana E. Morozova; Dmitry A. Shatskiy; Nadezhda V. Shikh; Evgeniya V. Shikh; Tatiana B. Andrushchyshina; Maria V. Lukina; Anastasia A. Kachanova; Zhannet A. Sozaeva; Sherzod P. Abdullaev; Natalia P. Denisenko; Kristina A. Ryzhikova is a Medicine article available to read on EtoBox.
What is Effect of CYP2C9 , PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen about?
## Abstract ## Objectives Patients undergoing cardiac surgery develop post-sternotomy pain syndrome. The aim of this study was evaluation of the influence of CYP2C9, PTGS-1 and PTGS-2 genes polymorphisms on the efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery. ## Methods The study included 90 patients undergoing cardiac surgery. A real-time polymerase chain reaction was used for the detection of single nucleotide polymorphisms (SNP). Pain intensity was measured by the Numeric Rating Scale (NRS). Dyspeptic symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS). Acute kidney injury (AKI) was determined by Kidney Disease Improving Global Outcomes criteria. ## Results Pain intensity by the NRS score was significantly higher in patients with CYP2C9\*3 АA genotype compared to АC genotype: 7 [1,10] and 6 [2,7] (p=0.003); 7 [1,10] and 6 [2,7] (p=0.04); 6 [0; 10] and 5 [2,6] (p=0.04); 5 [0; 8] and 3 [0; 8] (p=0.02), on days 1, 2, 3 and 5 in the postoperative period, respectively. GSRS score was higher in patients with CYP2C9\*2 CT genotype compared to CС genotype: 19 [15; 42] and 18 [15,36]
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- Author
- Dmitry A. Sychev; Tatiana E. Morozova; Dmitry A. Shatskiy; Nadezhda V. Shikh; Evgeniya V. Shikh; Tatiana B. Andrushchyshina; Maria V. Lukina; Anastasia A. Kachanova; Zhannet A. Sozaeva; Sherzod P. Abdullaev; Natalia P. Denisenko; Kristina A. Ryzhikova
- Publisher
- Walter de Gruyter GmbH
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)