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Association of Lactobacillus, Firmicutes, Bifidobacterium, Clostridium, and Enterococcus with colorectal cancer in Iranian patients by Zahra Elahi; Aref Shariati; Narjess Bostanghadiri; Leila Dadgar-Zankbar; Shabnam Razavi; Samira Norzaee; Saba Vazirbani Arasi; Davood Darban-Sarokhalil is a Medicine article available to read on EtoBox.

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## Background Colorectal cancer (CRC) is one of the primary causes of cancer-associated deaths worldwide, and growing evidence shows that alteration in the gut microbiota may be a contributing factor to the development and progression of the disease. This study investigates the correlation between CRC and specific intestinal microbiota abundance, including Firmicutes, Lactobacillus, Enterococcus, Clostridium, and Bifidobacterium. ## Material and methods In this study, 100 CRC samples and adjacent normal tissues were obtained from Iranian patients. Afterward, we assessed the abundance of the mentioned bacteria in matched tumor and normal tissue samples from 100 CRC patients, by TaqMan quantitative real-time polymerase chain reaction (qPCR). ## Results Most of the patients (55 %) had grade II cancer (moderately differentiated), followed by grade III (poorly Differentiated) in 19 %, and the distribution of the tumor location was 65 % in the colon and 35 % in the rectum. Our research showed a substantial difference in the relative abundance of specific bacteria in tumors and healthy tissues. To this end, four genera of bacteria, including Bifidobacterium, Lactobacillus, Clostridium, an

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Author

Zahra Elahi; Aref Shariati; Narjess Bostanghadiri; Leila Dadgar-Zankbar; Shabnam Razavi; Samira Norzaee; Saba Vazirbani Arasi; Davood Darban-Sarokhalil

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Physical Sciences)