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Some Endocrine Characteristics of Early Menarche, a Risk Factor for Breast Cancer, Are Preserved Into Adulthood by D. Apter; M. Reinilä; R. Vihko is a Medicine article available to read on EtoBox.

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Early menarche is a risk factor for breast cancer. In a longitudinal manner, we have investigated the endocrine features of girls with early menarche. This study extends our investigations to the third decade of life in a cohort of girls followed up for 13 years. The group studied comprised 44 women, 2 0 3 1 years of age. Eleven women had had their menarche before 12.0 years, I 4 women at 12.04 2.9 years and I 9 women at 13.0 years or more. The women who had had early menarche had higher serum oestradiol concentrations during the follicular phase of the menstrual cycle than the women who had had their menarche later. The serum oestradiol concentrations increased rapidly at the beginning of cycle in these "early menarche" women. If there is a threshold which serum oestradiol concentrations must exceed to increase the risk of breast cancer, then these women have more days at risk than other women. In addition, the serum SHBG sex-hormonabinding globulin) concentration was about 30 sb lower in the follicular-phase specimens of the women who had had their menarche before 12.0 years compared with those who had had their menarche at 13.0 years. Our data therefore indicate that women with

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Author

D. Apter; M. Reinilä; R. Vihko

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1989

Language

EN

Field

Medicine (Health Sciences)