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Plasma Circulating Mirnas Profiling for Identification of Potential Breast Cancer Early Detection Biomarkers by A Rashid Jusoh; Sivanesan Mohan; Tan Lu Ping; Tengku Ahmad Damitri Al Astani Tengku Din; Juhara Haron; Roslini Romli; Hasnan Jaafar; Siti Norasikin Nafi; Tuan Ismail Tuan Salwani; Maya Mazuwin Yahya is a Medicine article available to read on EtoBox.

What is Plasma Circulating Mirnas Profiling for Identification of Potential Breast Cancer Early Detection Biomarkers about?

## Objective: This study aimed to characterize the mirna expression profiles from plasma samples of our local breast cancer patients in comparison to healthy control by using mirna pcr array. ## Methods: In this study, plasma mirna profiles from eight early-stage breast cancer patients and nine age-matched (± 2 years) healthy controls were characterized by mirna array-based approach, followed by differential gene expression analysis, independent t-test and construction of receiver operating characteristic (roc) curve to determine the capability of the assays to discriminate between breast cancer and the healthy control. ## Results: Based on the 372-mirnas microarray profiling, a set of 40 differential mirnas was extracted regarding to the fold change value at 2 and above. we further sub grouped 40 mirnas of breast cancer patients that were significantly expressed at 2-fold change and higher. in this set, we discovered that 24 mirnas were significantly upregulated and 16 mirnas were significantly downregulated in breast cancer patients, as compared to the mirna expression of healthy subjects. roc curve analysis revealed that seven mirnas (mir-125b-5p, mir-142-3p, mir-145-5p, mir-193

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Author

A Rashid Jusoh; Sivanesan Mohan; Tan Lu Ping; Tengku Ahmad Damitri Al Astani Tengku Din; Juhara Haron; Roslini Romli; Hasnan Jaafar; Siti Norasikin Nafi; Tuan Ismail Tuan Salwani; Maya Mazuwin Yahya

Publisher

EpiSmart Science Vector Ltd

Published

2021

Language

EN

Field

Medicine (Health Sciences)