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Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES) by Sabbir Ahmed; Caroline P Owen; Karen James; Chirag K Patel; Mijal Patel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES) about?

We report the initial results of the synthesis and biochemical evaluation of a series of aminosulfonate based compounds of phenol and the determination of the pK a of the parent phenol in an attempt to investigate the role of this physicochemical factor in the irreversible inhibition of the enzyme estrone sulfatase (ES). The results of the study show that there is a strong correlation between the observed pK a and inhibitory activity. We postulate that the stability of the phenoxide ion, as indicated by the acid dissociation constant, is an important factor in the irreversible inhibition of this enzyme.

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Author

Sabbir Ahmed; Caroline P Owen; Karen James; Chirag K Patel; Mijal Patel

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)