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Copper-Catalyzed Annulation–Trifluoromethyl Functionalization of Enynones by Jia-Yin Wang; Sai Zhang; Yao Tang; Shenghu Yan; Guigen Li is a Chemistry article available to read on EtoBox.

What is Copper-Catalyzed Annulation–Trifluoromethyl Functionalization of Enynones about?

The Cu(I)-catalyzed annulation−halotrifluoromethylation and cyanotrifluoromethylation of enynones have been established, enabling multibond formations of the synthesis of quaternary carboncentered 1-indanones in moderate to good chemical yields. The reaction of enynones with Togni's reagent and chloro-or bromotrimethylsilane afforded halo-and CF 3 -containing 1-indenones. However, the addition of K 3 PO 4 as a base into the catalytic system led to forming cyano-anchored (Z)-1-indanones as major stereoisomeric products. This strategy exhibits remarkable compatibility with a wide range of enynones.

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Author

Jia-Yin Wang; Sai Zhang; Yao Tang; Shenghu Yan; Guigen Li

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)