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Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study by Zhen-Ni Zhao; Zi-Qian Zhang; Qian-Qian Wang; Bao-Ling Zhao; He Wang; Xue-Jun Ge; Fei-Yan Yu is a Medicine article available to read on EtoBox.

What is Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study about?

## Introduction Previous observational studies have associated periodontitis (PD) with migraine; however, the results are inconclusive and the causality of the association between PD and migraine remains unclear. This two-sample Mendelian randomization (MR) study was performed to explore the bi-directional causal relationship between PD and migraine. ## Methods To investigate the relationship between PD (17,353 cases; 28,210 controls) and migraine (1072 cases; 360,122 controls), we used genetic tools from the largest available genome-wide association study of European descent. Inverse variance-weighted (IVW) and a series of sensitivity analyses were used to explore the association between migraine and PD. We performed an MR study using seven SNPs (single nucleotide polymorphisms) as instrumental variables for PD to investigate the causal relationship between migraine and PD. ## Results We found no significant causal relationship between PD and migraine (odds ratio, OR = 1.000; 95% confidence interval, CI = 0.99–1.00; __p__ = 0.65). Similarly, no evidence supported a causal relationship between migraine and PD (OR = 0.07; CI = 2.04 × 10^–9^–2.65 × 10^6^; __p__ = 0.77). A sensitivity

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Author

Zhen-Ni Zhao; Zi-Qian Zhang; Qian-Qian Wang; Bao-Ling Zhao; He Wang; Xue-Jun Ge; Fei-Yan Yu

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)