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Cloning, Sequencing, and Expressional Analysis of the Chick Homologue of Follistatin by D. J. Connolly; K. Patel; E. A. P. Seleiro; D. G. Wilkinson; J. Cooke is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cloning, Sequencing, and Expressional Analysis of the Chick Homologue of Follistatin about?

Follistatin, a secreted glycoprotein, has been shown to act as a potent neural inducer during early amphibian development. The function of this protein during embryogenesis in higher vertebrates is unclear, and to further our understanding of its role we have cloned, sequenced, and performed an in-depth expressional analysis of the chick homologue of follistatin. In addition we also describe the expression pattern of activin PA and activin p B, proteins that have previously been shown to be able to interact with follistatin. In this study we show that the expression of follistatin and the activins do not always overlap. Follistatin was first detected in Hensen's node and subsequently in the region described by Spratt [ 19521 as the neuralising area. In older embryos it was also expressed in a highly dynamic manner in the hindbrain as well as in the somites. We also present evidence that follistatin may have a later role in the resegmentation of the somites. We were unable to detect the expression of activin PA during early embryogenesis, whereas activin PB was first expressed in the extending primitive streak and subsequently in the neural folds. The results from this study are con

Who reads Cloning, Sequencing, and Expressional Analysis of the Chick Homologue of Follistatin?

Author

D. J. Connolly; K. Patel; E. A. P. Seleiro; D. G. Wilkinson; J. Cooke

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0192-253X)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)