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Real-time screening of hydrazine by a NIR fluorescent probe with low cytotoxicity in living cells and its multiple applications: Optimization using Box-Behnken Design by Serkan Erdemir; Mehmet Oguz; Sait Malkondu is a Engineering article available to read on EtoBox.

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Hydrazine (N 2 H 4 ) finds use in a wide spectrum of industries. However, it is highly hazardous and leads to the environmental pollution and the subsequent potential health risk. Therefore, the development of new sensing techniques for pollutants is a significant challenge. Herein, we report a fluorescence and colorimetric sensing of N 2 H 4 through a D-π-A structure including benzothiazole and benzothiazolium units as electron donating and withdrawing cores, respectively. The sensing mechanism is based on the ratiometric change of emission intensity resulted from the change in electron density distribution in the presence of N 2 H 4 triggered by selective nucleophilic addition to -C --N + -, not reported yet such detection strategy for N 2 H 4 . The response is very selective over a series of anions, cations, amines, amino acids. Besides, the low cytotoxic probe is able to visualize the subcellular distribution of N 2 H 4 in HeLa cells by confocal fluorescence microscopy. The sensing process parameters such as N 2 H 4 level, time and pH are modeled by Box-Behnken design with response surface methodology. The practical applications such as a low-cost electronic diagnostic platform

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Author

Serkan Erdemir; Mehmet Oguz; Sait Malkondu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Engineering (Physical Sciences)