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RETN gene polymorphisms interact with alcohol dependence in association with depression by Xiaoyan Xu; Zeping Xu; Fan Zhou; Lijing Chen; Huai Li; Michelle Niculescu; Guanghui Shen; Liujun Wu; Wei Wang; Li Chen; Yanlong Liu; Jue He; Fan Wang; Fan Yang is a Medicine article available to read on EtoBox.

What is RETN gene polymorphisms interact with alcohol dependence in association with depression about?

## Abstract ## Background Previous studies suggest that alcohol dependence is associated with increased risk of depression. The occurrence of depressive symptoms is related to polymorphisms in various genetic regions. This study aimed to investigate the interaction of __RETN__ gene polymorphisms (rs1477341, rs3745368) with alcohol dependence on depressive symptoms in adult male during acute alcohol withdrawal. ## Methods A total of 429 male adults were recruited in this study. Alcohol dependence was assessed using the Michigan alcoholism screening test (MAST). Depression was assessed using the 20‐item self‐rating depression scale (SDS). Hierarchical regression analysis was used to evaluate the interaction between genes and alcohol dependence on depression. Region of significance (ROS) test was used to explain the interaction effect. The strong and weak forms of the differential susceptibility and diathesis models were used to determine which fits the data better. ## Results Our results showed that MAST scores were significantly positively associated with SDS scores (__r__ = 0.23, __p__ < 0.01) in alcohol‐dependent patients during alcohol withdrawal. The interaction between genotype

Who reads RETN gene polymorphisms interact with alcohol dependence in association with depression?

Author

Xiaoyan Xu; Zeping Xu; Fan Zhou; Lijing Chen; Huai Li; Michelle Niculescu; Guanghui Shen; Liujun Wu; Wei Wang; Li Chen; Yanlong Liu; Jue He; Fan Wang; Fan Yang

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)