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Whole Mitochondrial Genome Sequencing of Domestic Horses Reveals Incorporation of Extensive Wild Horse Diversity During Domestication by Sebastian Lippold; Nicholas J Matzke; Monika Reissmann; Michael Hofreiter is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background DNA target enrichment by micro-array capture combined with high throughput sequencing technologies provides the possibility to obtain large amounts of sequence data (e.g. whole mitochondrial DNA genomes) from multiple individuals at relatively low costs. Previously, whole mitochondrial genome data for domestic horses (__Equus caballus__) were limited to only a few specimens and only short parts of the mtDNA genome (especially the hypervariable region) were investigated for larger sample sets. ## Results In this study we investigated whole mitochondrial genomes of 59 domestic horses from 44 breeds and a single Przewalski horse (__Equus przewalski__) using a recently described multiplex micro-array capture approach. We found 473 variable positions within the domestic horses, 292 of which are parsimony-informative, providing a well resolved phylogenetic tree. Our divergence time estimate suggests that the mitochondrial genomes of modern horse breeds shared a common ancestor around 93,000 years ago and no later than 38,000 years ago. A Bayesian skyline plot (BSP) reveals a significant population expansion beginning 6,000-8,000 years ago with an ongoing exponential growth

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Author

Sebastian Lippold; Nicholas J Matzke; Monika Reissmann; Michael Hofreiter

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1471-2148)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)