Can I read Enhancement of Cellular Uptake and Antitumor Efficiencies of Micelles with Phosphorylcholine on EtoBox?

Enhancement of Cellular Uptake and Antitumor Efficiencies of Micelles with Phosphorylcholine by Song Tu; Yuan-Wei Chen; Yong-Bin Qiu; Kun Zhu; Xiang-Lin Luo is a Materials Science article available to read on EtoBox.

What is Enhancement of Cellular Uptake and Antitumor Efficiencies of Micelles with Phosphorylcholine about?

## Abstract Internalization of drug delivery micelles into cancer cells is a crucial step for antitumor therapeutics. Novel amphiphilic star‐shaped copolymers with zwitterionic phosphorylcholine (PC) block, 6‐arm star poly(ε‐caprolactone)‐b‐poly(2‐methacryloyloxyethyl phosphorylcholine) (6sPCL‐b‐PMPC), have been developed for encapsulation of poorly water‐soluble drugs and enhancement of their cellular uptake. The star‐shaped copolymers were synthesized by a combination of ring‐opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The copolymers self‐assembled to form spherical micelles with low critical micelle concentration (CMC). The sizes of the micelles range from 80 to 170 nm and increase 30 ≈ 80% after paclitaxel (PTX) loading. Labeled with fluorescein isothiocyanate (FITC), the micelles were confirmed by fluorescence microscopy to have been internalized efficiently by tumor cells. Direct visualization of the micelles within tumor cells by transmission electron microscopy (TEM) confirmed that the 6sPCL‐b‐PMPC micelles were more efficiently uptaken by tumor cells compared to PCL‐b‐PEG micelles. When incorporated with PTX, the 6sPCL‐b‐PMPC micelles show

Who reads Enhancement of Cellular Uptake and Antitumor Efficiencies of Micelles with Phosphorylcholine?

Author

Song Tu; Yuan-Wei Chen; Yong-Bin Qiu; Kun Zhu; Xiang-Lin Luo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)

Published

2011

Language

EN

Field

Materials Science (Physical Sciences)