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Differential effects of biologic versus bisphosphonate inhibition of wear debris‐induced osteolysis assessed by longitudinal micro‐CT by Ryosuke Tsutsumi; Colleen Hock; C. Dustin Bechtold; Steven T. Proulx; Susan V. Bukata; Hiromu Ito; Hani A. Awad; Takashi Nakamura; Regis J. O'Keefe; Edward M. Schwarz is a Medicine article available to read on EtoBox.
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## Abstract Aseptic loosening of total joint replacements is caused by wear debris‐induced osteoclastic bone resorption, for which bisphosphonates (BPs) and RANK antagonists have been developed. Although BPs are effective in preventing metabolic bone loss, they are less effective for inflammatory bone loss. Because this difference has been attributed to the antiapoptotic inflammatory signals that protect osteoclasts from BP‐induced apoptosis, but not RANK antagonists, we tested the hypothesis that osteoprotegerin (OPG) is more effective in preventing wear debris‐induced osteolysis than zoledronic acid (ZA) or alendronate (Aln) in the murine calvaria model using in vivo micro‐CT and traditional histology. Although micro‐CT proved to be incompatible with titanium (Ti) particles, we were able to demonstrate a 3.2‐fold increase in osteolytic volume over 10 days induced by polyethylene (PE) particles versus sham controls (0.49 ± 0.23mm^3^ versus 0.15 ± 0.067mm^3^; __p__ < 0.01). Although OPG and high‐dose ZA completely inhibited this PE‐induced osteolysis (__p__ < 0.001), pharmacological doses of ZA and Aln were less effective but still reached statistical significance (__p__ < 0.05). T
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- Author
- Ryosuke Tsutsumi; Colleen Hock; C. Dustin Bechtold; Steven T. Proulx; Susan V. Bukata; Hiromu Ito; Hani A. Awad; Takashi Nakamura; Regis J. O'Keefe; Edward M. Schwarz
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)