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The study focuses on the design and synthesis of 28 1,8-naphthyridine-3-carbonitrile derivatives, evaluated for their anti-mycobacterial activity against Mycobacterium tuberculosis. Among the compounds, ANA-12 exhibited the most potent activity with a minimum inhibitory concentration (MIC) of 6.25 mg/mL, while others showed moderate to good efficacy. The compounds demonstrated low cytotoxicity towards human embryonic kidney cells, indicating their potential as new anti-tuberculosis agents.

Author

wanda oliviya

Language

EN