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The Role of Iron in T ‐Butyl Hydroperoxide‐induced Lipid Peroxidation and Hepatotoxicity in Rats by Maged Younes; Alexander Wess is a Environmental Science article available to read on EtoBox.

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## Abstract Treatment of rats with 100 mg kg^−1^ __t__‐butyl hydroperoxide led to an enhanced ethane exhalation as a marker of __in vivo__ lipid peroxidation, as well as a moderate hepatoxicity as evidenced by a rise in plasma activities of liver‐specific enzymes (glutamate‐pyruvate transaminase and sorbitol dehydrogenase) and an increase in hepatic calcium content. Furthermore, a depletion of hepatic glutathione by 17% was observed. Apart from the loss of glutathione, all these effects were antagonized by pretreatment of rats with the potent iron chelator deferrioxamine and potentiated by pretreatment with low concentrations of FeSO~4~ having no pro‐oxidant activity __per se__; this was also the case in rats under conditions of iron overload (experimental haemochromatosis). These data indicate a close relationship between __t__‐butyl hydroperoxide‐induced lipid peroxidation and its hepatotoxicity, and point out the importance of iron in catalysing reinitiation (propagation) reactions of lipid peroxidation __in vivo__.

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Author

Maged Younes; Alexander Wess

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

1990

Language

EN

Field

Environmental Science (Physical Sciences)