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Can I read Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH) on EtoBox?
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH) by Douglas S. Johnson; Kay Ahn; Suzanne Kesten; Scott E. Lazerwith; Yuntao Song; Mark Morris; Lorraine Fay; Tracy Gregory; Cory Stiff; James B. Dunbar Jr.; Marya Liimatta; David Beidler; Sarah Smith; Tyzoon K. Nomanbhoy; Benjamin F. Cravatt is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH) about?
The synthesis and structure-activity relationships (SAR) of a series of benzothiophene piperazine and piperidine urea FAAH inhibitors is described. These compounds inhibit FAAH by covalently modifying the enzyme's active site serine nucleophile. Activity-based protein profiling (ABPP) revealed that these urea inhibitors were completely selective for FAAH relative to other mammalian serine hydrolases. Several compounds showed in vivo activity in a rat complete Freund's adjuvant (CFA) model of inflammatory pain.
Who reads Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Douglas S. Johnson; Kay Ahn; Suzanne Kesten; Scott E. Lazerwith; Yuntao Song; Mark Morris; Lorraine Fay; Tracy Gregory; Cory Stiff; James B. Dunbar Jr.; Marya Liimatta; David Beidler; Sarah Smith; Tyzoon K. Nomanbhoy; Benjamin F. Cravatt
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)