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Effects of Advanced Glycation End Products via Oxidative Stress on Beta Cells: Insights from in vitro and in vivo Studies and Update on Emerging Therapies by Ioanna A. Anastasiou; Konstantinos N. Tentolouris; Vaia Lambadiari; Ioanna Eleftheriadou; Maria Tektonidou; Nikolaos Tentolouris is a Chemistry article available to read on EtoBox.

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## Background: Protein, lipid, and nucleic acid glycation reactions begin and continue as a result of persistent hyperglycemia in patients with diabetes mellitus. Advanced glycated end products (AGEs) are a complex group of chemical moieties that are formed as a result of the glycation process and play an important role in the pathogenesis of diabetes mellitus. When AGEs interact with their cellular receptor (RAGE), numerous signaling pathways, including nuclear factor kappa-light-chainenhancer of activated B cells (NF-κB), c-Jun N-terminal kinase (JNK), and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), are activated, increasing oxidative stress. ## Objective: The aim of this review was to summarize in vitro and in vivo studies underlining the involvement of AGEs on beta cell dysfunction and death via oxidative stress. ## Methods: A literature search of publications published between 1912 and December 2022 was conducted using MEDLINE, EMBASE, and the Cochrane Library, with restrictions on articles written in English. ## Results: Recent insights have revealed that oxidative stress has a crucial role in the development of beta cell dysfunction and

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Author

Ioanna A. Anastasiou; Konstantinos N. Tentolouris; Vaia Lambadiari; Ioanna Eleftheriadou; Maria Tektonidou; Nikolaos Tentolouris

Publisher

Bentham Science Publishers Ltd.

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)