Can I read Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells on EtoBox?

Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells by Carvalho, J. L.; Miranda, M.; Fialho, A. K.; Castro-Faria-Neto, H.; Anatriello, E.; Keller, A. C.; Aimbire, F.; Chu, Hong Wei is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells about?

COPD is a prevalent lung disease with significant impacts on public health. Affected airways exhibit pulmonary neutrophilia and consequent secretion of pro-inflammatory cytokines and proteases, which result in lung emphysema. Probiotics act as nonspecific modulators of the innate immune system that improve several inflammatory responses. To investigate the effect of __Lactobacillus rhamnosus__ (__Lr__) on cigarette smoke (CS)-induced COPD C57Bl/6 mice were treated with __Lr__ during the week before COPD induction and three times/week until euthanasia. For __in vitro__ assays, murine bronchial epithelial cells as well as human bronchial epithelial cells exposed to cigarette smoke extract during 24 hours were treated with Lr 1 hour before CSE addition. __Lr__ treatment attenuated the inflammatory response both in the airways and lung parenchyma, reducing inflammatory cells infiltration and the production of pro-inflammatory cytokines and chemokines. Also, __Lr__-treated mice presented with lower metalloproteases in lung tissue and lung remodeling. In parallel to the reduction in the expression of TLR2, TLR4, TLR9, STAT3, and NF-κB in lung tissue, __Lr__ increased the levels of IL-10

Who reads Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells?

Author

Carvalho, J. L.; Miranda, M.; Fialho, A. K.; Castro-Faria-Neto, H.; Anatriello, E.; Keller, A. C.; Aimbire, F.; Chu, Hong Wei

Publisher

Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)