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The document discusses the etiology and pathophysiology of Cushing syndrome and adrenal insufficiency, detailing the roles of the Hypothalamic-Pituitary-Adrenal (HPA) axis in cortisol regulation. Cushing syndrome results from chronic hypercortisolism due to various causes, including iatrogenic factors and ACTH-secreting tumors, while adrenal insufficiency arises from inadequate hormone production, primarily due to adrenal gland dysfunction or suppression of the HPA axis. The clinical implications of these c

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apersonalaone

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EN