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Central Angiotensin Modulation of Baroreflex Control of Renal Sympathetic Nerve Activity in the Rat: Influence of Dietary Sodium by G. F. DiBona is a Medicine article available to read on EtoBox.

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## Abstract **Aim:** Administration of angiotensin II (angII) into the cerebral ventricles or specific brain sites impairs arterial baroreflex regulation of renal sympathetic nerve activity (SNA). Further insight into this effect was derived from: (a) using specific non‐peptide angII receptor antagonists to assess the role of endogenous angII acting on angII receptor subtypes, (b) microinjection of angII receptor antagonists into brain sites behind an intact blood–brain barrier to assess the role of endogenous angII of brain origin and (c) alterations in dietary sodium intake, a known physiological regulator of activity of the renin–angiotensin system (RAS), to assess the ability to physiologically regulate the activity of the brain RAS. **Methods:** In rats in balance on low, normal or dietary sodium intake, losartan or candesartan was injected into the lateral cerebral ventricle or the rostral ventrolateral medulla (RVLM) and the effects on basal renal SNA and the arterial baroreflex sigmoidal relationship between renal SNA and arterial pressure were determined. **Results:** With both routes of administration, the effects were proportional to the activity of the RAS as indexed by

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Author

G. F. DiBona

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)

Published

2003

Language

EN

Field

Medicine (Life Sciences)