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Surveillance Colonoscopy in Patients with Inflammatory Bowel Disease: Comparison of Random Biopsy vs. Targeted Biopsy Protocols by Ute Günther; Dajana Kusch; Frank Heller; Nataly Bürgel; Silke Leonhardt; Severin Daum; Britta Siegmund; Christoph Loddenkemper; Maria Grünbaum; Heinz-Johannes Buhr; Jörg-Dieter Schulzke; Martin Zeitz; Christian Bojarski is a Medicine article available to read on EtoBox.
What is Surveillance Colonoscopy in Patients with Inflammatory Bowel Disease: Comparison of Random Biopsy vs. Targeted Biopsy Protocols about?
## Background: Endoscopic surveillance in patients with long-standing inflammatory bowel disease (ibd) improves early detection of intraepithelial neoplasia (ien). we aimed to compare three different endoscopic surveillance strategies in the detection of ien. ## Methods: One hundred fifty surveillance colonoscopies (ulcerative colitis, uc n = 141; crohn's disease, cd n = 9) were carried out. random quadrant biopsies were taken (group i, n = 50). chromoendoscopy with indigo carmine was performed and subsequently quadrant biopsies were collected (group ii, n = 50). patients in group iii (n = 50) underwent confocal endomicroscopy (cem), and cem-guided as well as random quadrant biopsies were taken (group iii, n = 50). the findings of cem were correlated to conventional histology. patients with high-grade ien underwent surgery or strict follow-up by patients' request. ## Results: In group i (1531 biopsies), no ien was detected by histology. in group ii (1,811 biopsies), chromoendoscopy-guided biopsies revealed high-grade ien in two patients (4% detection rate). in four patients of group iii (1477 biopsies), areas with high-grade ien were clearly visible by cem and confirmed by histolog
Who reads Surveillance Colonoscopy in Patients with Inflammatory Bowel Disease: Comparison of Random Biopsy vs. Targeted Biopsy Protocols?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ute Günther; Dajana Kusch; Frank Heller; Nataly Bürgel; Silke Leonhardt; Severin Daum; Britta Siegmund; Christoph Loddenkemper; Maria Grünbaum; Heinz-Johannes Buhr; Jörg-Dieter Schulzke; Martin Zeitz; Christian Bojarski
- Publisher
- Springer Science and Business Media LLC
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)