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Can I read Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms on EtoBox?
Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms by Kebede, Alebachew Messele; Tadesse, Fitsum Girma; Feleke, Adey Desta; Golassa, Lemu; Gadisa, Endalamaw is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms about?
## Background: Plasmodium vivax merozoite surface protein 3α (pvmsp3α) is a promising vaccine candidate which has shown strong association with immunogenicity and protectiveness. its use is however complicated by evolutionary plasticity features which enhance immune evasion. low complexity regions (lcrs) provide plasticity in surface proteins of plasmodium species, but its implication in vaccine design remain unexplored. here population genetic, comparative phylogenetic and structural biology analysis was performed on the gene encoding pvmsp3α. ## Results: Three lcrs were found in pvmsp3α block ii. both the predicted tertiary structure of the protein and the phylogenetic trees based on this region were influenced by the presence of the lcrs. the lcrs were mainly b cell epitopes within or adjacent. in addition a repeat motif mimicking one of the b cell epitopes was found within the pvmsp3a block ii low complexity region. this particular b cell epitope also featured rampant alanine substitutions which might impair antibody binding. ## Conclusion: The findings indicate that pvmsp3α block ii possesses lcrs which might confer a strong phenotypic plasticity. the phenomenon of phenotypic
Who reads Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kebede, Alebachew Messele; Tadesse, Fitsum Girma; Feleke, Adey Desta; Golassa, Lemu; Gadisa, Endalamaw
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6807)
- Published
- 2019
- Language
- EN
- ISBN
- 9781290001908
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)