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A Model for Loading-dependent Growth, Development, and Adaptation of Tendons and Ligaments by Tishya A.L. Wren; Gary S. Beaupré; Dennis R. Carter is a Medicine article available to read on EtoBox.

What is A Model for Loading-dependent Growth, Development, and Adaptation of Tendons and Ligaments about?

The geometric and material properties of tendons and ligaments change during growth and development. While some of the changes occur in the absence of mechanical loading, normal development requires the mechanical stimulus provided by normal physical activity. We have developed an analytical framework for quantitatively describing changes in uniaxial tendon and ligament properties throughout ontogeny. In our approach, cross-sectional area, modulus, and strength undergo baseline levels of development due to inherent time-dependent biological influences. The properties also change in response to mechanobiological influences by adapting to maintain a constant daily strain stimulus under changing load conditions. We have implemented a computer algorithm based on these concepts and obtained results consistent with experimental observations of normal tendon and ligament growth and development reported by other investigators. Additional results suggest that these concepts can also explain tendon and ligament adaptation to increased or decreased loading experienced during development. Published by Elsevier Science Ltd.

Who reads A Model for Loading-dependent Growth, Development, and Adaptation of Tendons and Ligaments?

Author

Tishya A.L. Wren; Gary S. Beaupré; Dennis R. Carter

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)

Published

1997

Language

EN

Field

Medicine (Health Sciences)