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Structural Plasticity of Dentate Granule Cell Mossy Fibers During the Development of Limbic Epilepsy by Steve C. Danzer; Xiaoping He; Andreas W. Loepke; James O. McNamara is a Neuroscience article available to read on EtoBox.

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## Abstract Altered granule cell≫CA3 pyramidal cell synaptic connectivity may contribute to the development of limbic epilepsy. To explore this possibility, granule cell giant mossy fiber bouton plasticity was examined in the kindling and pilocarpine models of epilepsy using green fluorescent protein‐expressing transgenic mice. These studies revealed significant increases in the frequency of giant boutons with satellite boutons 2 days and 1 month after pilocarpine status epilepticus, and increases in giant bouton area at 1 month. Similar increases in giant bouton area were observed shortly after kindling. Finally, both models exhibited plasticity of mossy fiber giant bouton filopodia, which contact GABAergic interneurons mediating feedforward inhibition of CA3 pyramids. In the kindling model, however, all changes were fleeting, having resolved by 1 month after the last evoked seizure. Together, these findings demonstrate striking structural plasticity of granule cell mossy fiber synaptic terminal structure in two distinct models of adult limbic epileptogenesis. We suggest that these plasticities modify local connectivities between individual mossy fiber terminals and their targets,

Who reads Structural Plasticity of Dentate Granule Cell Mossy Fibers During the Development of Limbic Epilepsy?

Author

Steve C. Danzer; Xiaoping He; Andreas W. Loepke; James O. McNamara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)