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Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis by Ren, Zhi-li; Wang, Chao-dong; Wang, Tao; Ding, Hui; Zhou, Ming; Yang, Nan; Liu, Yan-yong; Chan, Piu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson's disease. Ganoderma lucidum (GL) has emerged as a novel agent that protects neurons from oxidative stress. However, the detailed mechanisms underlying GL-induced neuroprotection have not been documented. In this study, we investigated the neuroprotective effects of GL extract (GLE) and the underlying mechanisms in the classic MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced mouse model of PD. Mice were injected with MPTP to induce parkinsonism. Then the mice were administered GLE (400 mg kg d, ig) for 4 weeks. We observed that GLE administration significantly improved locomotor performance and increased tyrosine hydroxylase expression in the substantia nigra pars compact (SNpc) of MPTP-treated mice. In in vitro study, treatment of neuroblastoma neuro-2a cells with 1-methyl-4-phenylpyridinium (MPP, 1 mmol/L) caused mitochondrial membrane potential collapse, radical oxygen species accumulation, and ATP depletion. Application of GLE (800 μg/mL) protected neuroblastoma neuro-2a cells against MPP insult. Application of GLE also improved mitochondrial moveme

Who reads Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis?

Author

Ren, Zhi-li; Wang, Chao-dong; Wang, Tao; Ding, Hui; Zhou, Ming; Yang, Nan; Liu, Yan-yong; Chan, Piu

Publisher

Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1671-4083)

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)