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Brain response to complex visual stimuli in Parkinson's patients with hallucinations: A functional magnetic resonance imaging study by Blanca Ramírez-Ruiz; María-José Martí; Eduardo Tolosa; Carlos Falcón; Nuria Bargalló; Francesc Valldeoriola; Carme Junqué is a Medicine article available to read on EtoBox.
What is Brain response to complex visual stimuli in Parkinson's patients with hallucinations: A functional magnetic resonance imaging study about?
## Abstract Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one‐back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21‐face stimuli (activation condition) and three blocks of 21‐colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyru
Who reads Brain response to complex visual stimuli in Parkinson's patients with hallucinations: A functional magnetic resonance imaging study?
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- Author
- Blanca Ramírez-Ruiz; María-José Martí; Eduardo Tolosa; Carlos Falcón; Nuria Bargalló; Francesc Valldeoriola; Carme Junqué
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)