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Construction of Magnetic-carbon-quantum-dots-probe-labeled Apoferritin Nanocages for Bioimaging and Targeted Therapy by Hanchun Yao; Li Su; Man Zeng; Li Cao; Weiwei Zhao; Chengqun Chen; Bin Du; Jie Zhou is a Materials Science article available to read on EtoBox.
What is Construction of Magnetic-carbon-quantum-dots-probe-labeled Apoferritin Nanocages for Bioimaging and Targeted Therapy about?
Carbon dots (CDs) are one of the most highlighted carbon-based materials for biological applications, such as optical imaging nanoprobes, which are used for labeling cells in cancer treatment mainly due to their biocompatibility and unique optical properties. In this study, gadolinium (Gd)-complex-containing CDs were obtained through a one-step microwave method to develop multimodal nanoprobes integrating the advantages of optical and magnetic imaging. The obtained Gd-CDs exhibited highly fluorescent properties with excellent water solubility and biological compatibility. Natural apoferritin (AFn) nanocages, an excellent drug delivery carrier, are hollow in structure, with their pH-dependent, unfolding–refolding process at pH 2.0 and 7.4. The chemotherapeutic drug doxorubicin (DOX) can be highly effective and encapsulated into AFn cavity. A widely used tumor-targeting molecule, folic acid (FA), functionalized the surface of AFn to obtain an active tumor targeting effect on MCF-7 cells and malignant tumors in mice models. In this study, an AFn nanocarrier encapsulating high concentration of DOX labeled with magnetic and fluorescent Gd-CDs probe was developed. Gd-CDs exhibited a uniq
Who reads Construction of Magnetic-carbon-quantum-dots-probe-labeled Apoferritin Nanocages for Bioimaging and Targeted Therapy?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Hanchun Yao; Li Su; Man Zeng; Li Cao; Weiwei Zhao; Chengqun Chen; Bin Du; Jie Zhou
- Publisher
- Dove Medical Press Ltd.
- Published
- 2016
- Language
- EN
- Field
- Materials Science (Physical Sciences)