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Can I read A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome on EtoBox?
A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome by Danni Shi; Michael K. Dyck; Richard R. E. Uwiera; Jim C. Russell; Spencer D. Proctor; Donna F. Vine is a Medicine article available to read on EtoBox.
What is A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome about?
Epilepsy in women is influenced by endocrine status and antiepileptic drugs (AEDs), but without an animal model, the effects of endocrine variables and AEDs cannot be easily dissociated from the influence of epilepsy itself. Animal models have had limited utility because experimentally-induced seizures typically result in reproductive failure. This study was conducted to develop an improved animal model. The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague-Dawley rats. The selective estrogen receptor modulator raloxifene was administered 30 min before pilocarpine. An anticonvulsant barbiturate, pentobarbital, was injected 5-10 min after the onset of SE, and at least once thereafter to minimize acute convulsions. Mortality, morbidity, estrous cyclicity, and the ultimate success of the procedure (i.e. induction of recurrent, spontaneous seizures) were monitored. The combination of raloxifene and pentobarbital led to significantly improved estrous cyclicity compared to previous methods. Animals treated with raloxifene and pentobarbital became epileptic, as defined by the recurrence of spontaneous convulsions in the weeks after SE. Th
Who reads A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Danni Shi; Michael K. Dyck; Richard R. E. Uwiera; Jim C. Russell; Spencer D. Proctor; Donna F. Vine
- Publisher
- Endocrine Society; The Endocrine Society; Oxford University Press (ISSN 0021-972X)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)