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ADP‐ribosylation of nucleolar proteins in HeLa tumor cells by Norbert Leitinger; Jozefa Wesierska‐Gadek is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract ADP‐ribosylation reactions in nucleoli of exponentially growing HeLa cells were studied. Isolated nuclei or nucleoli were labeled with ^32^P‐NAD; then the nucleolar proteins were analyzed by 1‐dimensional and 2‐dimensional polyacrylamide gel electrophoresis (PAGE) and modified proteins were detected by autoradiography. The labeled nucleolar proteins were also chromatographically fractionated on DEAE‐cellulose. Electrophoretic analysis of total nucleolar and chromatographically purified proteins revealed that besides nuclear ADP‐ribosyltransferase and histones two characteristic nucleolar phosphoproteins numatrin/B23 and nucleolin/C23 were modified by ADP‐ribosylation.

Who reads ADP‐ribosylation of nucleolar proteins in HeLa tumor cells?

Author

Norbert Leitinger; Jozefa Wesierska‐Gadek

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)