Can I read Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity on EtoBox?

Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity by Dimitra Kovala-Demertzi; Angeliki Galani; Mavroudis A Demertzis; Stavroula Skoulika; Chronis Kotoglou is a Chemistry article available to read on EtoBox.

What is Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity about?

The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf) 2 L] 2 (where L is H 2 O or DMF, N,N-dimethylformamide) were investigated. The crystal and molecular structure of [Cu(tolf) 2 (DMF)] 2 was reported. Crystallographic data are as follows: monoclinic system, space group P 2 1 =n with cell constants a 1⁄4 9:068ð2Þ A, b 1⁄4 14:514ð3Þ A, c 1⁄4 22:826ð4Þ A, V 1⁄4 2948:9ð10Þ A 3 and Z 1⁄4 2. The crystal structure consists of binuclear, quadruply bridged neutral molecule with a Cu-Cu bond length of 2.6075(19) A. The complex is self-assembled via C-H-p intermolecular stacking interactions. Spectroscopic and electrochemical studies were reported. The superoxide dismutase activity is measured and compared with those of superoxide dismutase enzyme, SOD, the free ligand and related copper complexes with nonsteroidal anti-inflammatory drugs, NSAIDs. IC 50 value was measured by the Fridovich test (1:97 AE 0:17 lM), which showed that [Cu(tolf) 2 L] 2 is a good superoxide scavenger.

Who reads Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity?

Author

Dimitra Kovala-Demertzi; Angeliki Galani; Mavroudis A Demertzis; Stavroula Skoulika; Chronis Kotoglou

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)