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Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions by Peter Solar; Michal Hendrych; Martin Barak; Hana Valekova; Marketa Hermanova; Radim Jancalek is a Neuroscience article available to read on EtoBox.

What is Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions about?

Differential diagnosis of brain lesion pathologies is complex, but it is nevertheless crucial for appropriate clinical management. Advanced imaging methods, including diffusion-weighted imaging and apparent diffusion coefficient, can help discriminate between brain mass lesions such as glioblastoma, brain metastasis, brain abscesses as well as brain lymphomas. These pathologies are characterized by blood-brain barrier alterations and have been extensively studied. However, the changes in the blood-brain barrier that are observed around brain pathologies and that contribute to the development of vasogenic brain edema are not well described. Some infiltrative brain pathologies such as glioblastoma are characterized by glioma cell infiltration in the brain tissue around the tumor mass and thus affect the nature of the vasogenic edema. Interestingly, a common feature of primary and secondary brain tumors or tumor-like brain lesions characterized by vasogenic brain edema is the formation of various molecules that lead to alterations of tight junctions and result in blood-brain barrier damage. The resulting vasogenic edema, especially blood-brain barrier disruption, can be visualized usi

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Author

Peter Solar; Michal Hendrych; Martin Barak; Hana Valekova; Marketa Hermanova; Radim Jancalek

Publisher

Frontiers Media SA

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)