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What is E. coli Stress Response in Gene Overexpression about?

This study investigates the impact of strong overexpression of a heterologous α-glucosidase gene in Escherichia coli, revealing that the general stress response is suppressed, leading to reduced cell viability and protein production. The research highlights the competitive effects of product synthesis on host protein synthesis and the subsequent malfunction of the protein synthetic machinery. Additionally, it demonstrates that traditional strong expression systems can exacerbate issues such as mistranslatio

Author

jonasphua0626

Language

EN