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Pathologic Discrepancies Between Colposcopy-directed Biopsy and Loop Electrosurgical Excision Procedure of the Uterine Cervix in Women with Cytologic High-grade Squamous Intraepithelial Lesions by Se Ik Kim; Se Jeong Kim; Dong Hoon Suh; Kidong Kim; Jae Hong No; Yong Beom Kim is a Medicine article available to read on EtoBox.

What is Pathologic Discrepancies Between Colposcopy-directed Biopsy and Loop Electrosurgical Excision Procedure of the Uterine Cervix in Women with Cytologic High-grade Squamous Intraepithelial Lesions about?

## Objective To investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs). ## Methods We retrospectively identified 297 patients who underwent both CDB and LEEP for HSILs in cervical cytology between 2015 and 2018, and compared their pathologic results. Considering the LEEP to be the gold standard, we evaluated the diagnostic performance of CDB for identifying cervical intraepithelial neoplasia (CIN) grades 2 and 3, adenocarcinoma in situ, and cancer (HSIL+). We also performed age subgroup analyses. ## Results Among the study population, 90.9% (270/297) had pathologic HSIL+ using the LEEP. The diagnostic performance of CDB for identifying HSIL+ was as follows: sensitivity, 87.8%; specificity, 59.3%; balanced accuracy, 73.6%; positive predictive value, 95.6%; and negative predictive value, 32.7%. Thirty-three false negative cases of CDB included CIN2,3 (n=29) and cervical cancer (n=4). The pathologic HSIL+ rate in patients with HSIL− by CDB was 67.3% (33/49). CDB exhibited a significant difference in the diagnosis of HSIL+ c

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Author

Se Ik Kim; Se Jeong Kim; Dong Hoon Suh; Kidong Kim; Jae Hong No; Yong Beom Kim

Published

2019

Language

EN

Field

Medicine (Health Sciences)