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The document discusses the natural function of HLA-B27 and its potential pathogenic role in spondyloarthritis. HLA-B27 is strongly associated with spondyloarthritis and presents antigenic peptides to cytotoxic T lymphocytes as part of its natural function. Theories on how HLA-B27 may cause disease include presenting arthritogenic peptides or having unusual cell biology, such as forming homodimers that interact with immunoreceptors.

Author

peppa pig

Language

EN