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Can I read UNBRANCHED3 Expression and Inflorescence Development is Mediated by UNBRANCHED2 and the Distal Enhancer, KRN4, in Maize on EtoBox?
UNBRANCHED3 Expression and Inflorescence Development is Mediated by UNBRANCHED2 and the Distal Enhancer, KRN4, in Maize by Du, Yanfang; Liu, Lei; Peng, Yong; Li, Manfei; Li, Yunfu; Liu, Dan; Li, Xingwang; Zhang, Zuxin; Hake, Sarah is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is UNBRANCHED3 Expression and Inflorescence Development is Mediated by UNBRANCHED2 and the Distal Enhancer, KRN4, in Maize about?
Enhancers are __cis__-acting DNA segments with the ability to increase target gene expression. They show high sensitivity to DNase and contain specific DNA elements in an open chromatin state that allows the binding of transcription factors (TFs). While numerous enhancers are annotated in the maize genome, few have been characterized genetically. __KERNEL ROW NUMBER4__ (__KRN4__), an intergenic quantitative trait locus for kernel row number, is assumed to be a __cis__-regulatory element of __UNBRANCHED3__ (__UB3__), a key inflorescence gene. However, the mechanism by which __KRN4__ controls __UB3__ expression remains unclear. Here, we found that __KRN4__ exhibits an open chromatin state, harboring sequences that showed high enhancer activity toward the __35S__ and __UB3__ promoters. __KRN4__ is bound by UB2-centered transcription complexes and interacts with the __UB3__ promoter by three duplex interactions to affect __UB3__ expression. Sequence variation at __KRN4__ enhances __ub2__ and __ub3__ mutant ear fasciation. Therefore, we suggest that __KRN4__ functions as a distal enhancer of the __UB3__ promoter via chromatin interactions and recruitment of UB2-centered transcription co
Who reads UNBRANCHED3 Expression and Inflorescence Development is Mediated by UNBRANCHED2 and the Distal Enhancer, KRN4, in Maize?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Du, Yanfang; Liu, Lei; Peng, Yong; Li, Manfei; Li, Yunfu; Liu, Dan; Li, Xingwang; Zhang, Zuxin; Hake, Sarah
- Publisher
- Public Library of Science; San Francisco CA: Public Library of Science, ©2005-; Public Library of Science (PLoS) (ISSN 1553-7390)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)