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Circulating vitamin C and digestive system cancers: Mendelian randomization study by Susanna C. Larsson; Amy M. Mason; Mathew Vithayathil; Paul Carter; Siddhartha Kar; Ju-Sheng Zheng; Stephen Burgess is a Medicine article available to read on EtoBox.

What is Circulating vitamin C and digestive system cancers: Mendelian randomization study about?

## Background & aims: Vitamin c is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin c has a causal role in these cancers. the aim of this study was to utilize mendelian randomization to decipher the potential causal associations of vitamin c with risk of digestive system cancers. ## Methods: Ten genetic variants previously found to be significantly associated with circulating vitamin c were used as instrumental variables. effect size estimates for the genetic associations of the vitamin c-associated genetic variants with six major malignancies of digestive system were obtained from the finngen (n = 309 154) and uk biobank (n = 367 542) studies. results from the two studies were combined using meta-analysis. ## Results: Genetically predicted higher circulating vitamin c showed a suggestive association with lower risk of small intestine and colorectal cancer after accounting for multiple testing. the odds ratio per 1 standard deviation increment in circulating vitamin c was 0.55 (95% confidence interval 0.32-0.94; p = 0.029) for small intestine cancer and 0.84 (95% confidence interval 0.73-0.96; p = 0.01

Who reads Circulating vitamin C and digestive system cancers: Mendelian randomization study?

Author

Susanna C. Larsson; Amy M. Mason; Mathew Vithayathil; Paul Carter; Siddhartha Kar; Ju-Sheng Zheng; Stephen Burgess

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)