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Diagnosis and Treatment of Polonium Poisoning by Robert D. Jefferson; Ronald E. Goans; Peter G. Blain; Simon H.L. Thomas is a Medicine article available to read on EtoBox.

What is Diagnosis and Treatment of Polonium Poisoning about?

## Objectives: Interest in the clinical toxicology of (210)polonium ((210)po) has been stimulated by the poisoning of alexander litvinenko in 2006. this article reviews the clinical features, diagnosis, and treatment of acute radiation syndrome (ars) resulting from the ingestion of (210)po. physical characteristics: (210)po is a high-energy alpha-emitter (radioactive half-life 138 days) that presents a radiation hazard only if taken into the body, for example, by ingestion, because of the low range of alpha particles in biological tissues. as a result, external contamination does not cause radiation sickness. ## Toxicokinetics: Ingested (210)po is concentrated initially in red blood cells and then the liver, kidneys, spleen, bone marrow, gastrointestinal (gi) tract, and gonads. (210)po is excreted in urine, bile, sweat, and (possibly) breath and is also deposited in hair. after ingestion, unabsorbed (210)po is present in the faeces. the elimination half-life in man is approximately 30-50 days. in the absence of medical treatment, the fatal oral amount is probably in the order of 10-30 microg. ## Clinical presentation: If the absorbed dose is sufficiently large (e.g., >0.7 gy), (210

Who reads Diagnosis and Treatment of Polonium Poisoning?

Author

Robert D. Jefferson; Ronald E. Goans; Peter G. Blain; Simon H.L. Thomas

Publisher

Informa UK Limited

Published

2009

Language

EN

Field

Medicine (Health Sciences)