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Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review by Daniel H. Cooper; Ranuk Ramachandra; Felicia Ceban; Joshua D. Di Vincenzo; Taeho Greg Rhee; Rodrigo B. Mansur; Kayla M. Teopiz; Hartej Gill; Roger Ho; Bing Cao; Leanna M.W. Lui; Muhammad Youshay Jawad; Juliet Arsenault; Gia Han Le; Diluk Ramachandra; Ziji Guo; Roger S. McIntyre is a Psychology article available to read on EtoBox.

What is Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review about?

Glucagon-like peptide 1 (GLP-1) receptor agonists are widely used for glycemic control in patients with diabetes mellitus (DM) and are primarily indicated for type 2 diabetes mellitus (T2DM). GLP-1 receptor agonists have also been shown to have neuroprotective and antidepressant properties. Replicated evidence suggests that individuals with DM are significantly more likely to develop depression. Herein, we aim to investigate whether GLP-1 receptor agonists can be used prophylactically on patients with DM to lower the risk of incident depression. We conducted a systematic search for English-language articles published on the PubMed/MEDLINE, Scopus, Embase, APA, PsycInfo, Ovid and Google Scholar databases from inception to June 6, 2022. Four retrospective observational studies were identified that evaluated the neuroprotective effects of GLP-1 receptor agonists on incident depression in patients with DM. We found mixed results with regards to lowering the risk of incident depression, with two studies demonstrating a significant reduction in risk and two studies showing no such effect. A single study found that dulaglutide may lower susceptibility to depression. Our results were limit

Who reads Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review?

Author

Daniel H. Cooper; Ranuk Ramachandra; Felicia Ceban; Joshua D. Di Vincenzo; Taeho Greg Rhee; Rodrigo B. Mansur; Kayla M. Teopiz; Hartej Gill; Roger Ho; Bing Cao; Leanna M.W. Lui; Muhammad Youshay Jawad; Juliet Arsenault; Gia Han Le; Diluk Ramachandra; Ziji Guo; Roger S. McIntyre

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Psychology (Social Sciences)