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De novo hepatitis B virus infection from anti‐HBc‐positive donors in pediatric living donor liver transplantation by Zhi Feng Xi; Qiang Xia; Jian Jun Zhang; Xiao Song Chen; Long Zhi Han; Jian Jun Zhu; Si Yue Wang; De Kai Qiu is a Medicine article available to read on EtoBox.
What is De novo hepatitis B virus infection from anti‐HBc‐positive donors in pediatric living donor liver transplantation about?
## Objective The aim of this study was to analyze the incidence and risk factors of __de novo__ hepatitis B virus (HBV) infection from hepatitis B core antibody (anti‐HBc)‐positive donors in pediatric living donor liver transplantation (LDLT). ## Methods We retrospectively analyzed 46 recipients without pre‐liver transplantation (LT) HBV infection evidence who underwent LDLT from October 2006 to May 2011 in our center. HBV markers, including hepatitis B surface antigen (HBsAg) and antibody (anti‐HBs), anti‐HBc, hepatitis B e antigen (HBeAg) and antibody (anti‐HBe) were determined in both donors and recipients before LT and in recipients after LT. HBV DNA titer was measured if the recipients were strongly suspected of __de novo__ HBV infection. ## Results Without prophylaxis, __de novo__ HBV infection occurred in 11 of 46 recipients (23.9%) 6–36 months after LT. All 11 patients received grafts from anti‐HBc‐positive donors. The donors' baseline status and the characteristics of recipients at the time of transplantation were not associated with the acquisition of __de novo__ hepatitis B infection. The overall 2‐year survival rate of patients from anti‐HBc‐positive donors was 84.2%. T
Who reads De novo hepatitis B virus infection from anti‐HBc‐positive donors in pediatric living donor liver transplantation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Zhi Feng Xi; Qiang Xia; Jian Jun Zhang; Xiao Song Chen; Long Zhi Han; Jian Jun Zhu; Si Yue Wang; De Kai Qiu
- Publisher
- Wiley
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)