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Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy by George W. Sledge Jr.; Lawrence Einhorn; Catherine Nag; Karen House is a Medicine article available to read on EtoBox.

What is Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy about?

Background. Ondansetron hydrochloride is a selective serotonin subtype 3 (5HTJ receptor antagonist that has been shown to be an effective antiemetic in patients receiving cisplatin chemotherapy. Methods. This double-blind study compared the safety and efficacy of intravenous ondansetron with metoclopramide in patients receiving a 4-or 5-day regimen of cisplatin (20-40 mg/m2/day) combination chemotherapy. Forty-five patients were enrolled, and efficacy of the drug therapy could be studied for all 45. Patients were randomly assigned (1:1) to receive three daily intravenous doses of either 0.15 mg/kg ondansetron or 1 mg/kg metoclopramide. All patients were monitored daily for the number of emetic episodes (vomiting or retching), severity of nausea, adverse events, and laboratory safety parameters. Results. Seven (30%) patients who received ondansetron had no emetic episodes throughout the entire study period compared with two (9%) who received metoclopramide (P = 0.077). The greatest difference in antiemetic efficacy was seen on day 1, when 18 (78%) patients who received ondansetron had no emetic episodes compared with 3 (14%) patients who received metoclopramide (P < 0.001). Signific

Who reads Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy?

Author

George W. Sledge Jr.; Lawrence Einhorn; Catherine Nag; Karen House

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1992

Language

EN

Field

Medicine (Health Sciences)