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Can I read Early entry events in Echovirus 30 infection on EtoBox?
Early entry events in Echovirus 30 infection by Vandesande, Helena; Laajala, Mira; Kantoluoto, Tino; Ruokolainen, Visa; Lindberg, A. Michael; Marjomäki, Varpu is a Medicine article available to read on EtoBox.
What is Early entry events in Echovirus 30 infection about?
Echovirus 30 (E30), a member of the enterovirus B species, is a major cause of viral meningitis, targeting children and adults alike. While it is a frequently isolated enterovirus and the cause of several outbreaks all over the world, surprisingly little is known regarding its entry and replication strategy within cells. In this study, we used E30 strain Bastianni (E30B) generated from an infectious cDNA clone in order to study early entry events during infection in human RD cells. E30B required the newly discovered Fc echovirus receptor (FcRn) for successful infection, but not the coxsackievirus and adenovirus receptor (CAR) or decay-accelerating factor (DAF), although an interaction with DAF was observed. Double-stranded RNA replication intermediate was generated between 2 and 3 h postinfection (p.i.), and viral capsid production was initiated between 4 and 5 h p.i. The drugs affecting Rac1 (NSC 23766) and cholesterol (filipin III) compromised infection, whereas bafilomycin A1, dyngo, U-73122, wortmannin, and nocodazole did not, suggesting the virus follows an enterovirus-triggered macropinocytic pathway rather than the clathrin pathway. Colocalization with early endosomes and in
Who reads Early entry events in Echovirus 30 infection?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Vandesande, Helena; Laajala, Mira; Kantoluoto, Tino; Ruokolainen, Visa; Lindberg, A. Michael; Marjomäki, Varpu
- Publisher
- American Society for Microbiology (ISSN 0022-538X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)