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Advances in Hepatitis E Virus Biology and Pathogenesis by Lin, Shaoli (author);Zhang, Yan-Jin (author) is a Medicine article available to read on EtoBox.

What is Advances in Hepatitis E Virus Biology and Pathogenesis about?

Hepatitis E virus (HEV) is one of the causative agents for liver inflammation across the world. HEV is a positive-sense single-stranded RNA virus. Human HEV strains mainly belong to four major genotypes in the genus Orthohepevirus A, family Hepeviridae. Among the four genotypes, genotype 1 and 2 are obligate human pathogens, and genotype 3 and 4 cause zoonotic infections. HEV infection with genotype 1 and 2 mainly presents as acute and self-limiting hepatitis in young adults. However, HEV infection of pregnant women with genotype 1 strains can be exacerbated to fulminant hepatitis, resulting in a high rate of case fatality. As pregnant women maintain the balance of maternalfetal tolerance and effective immunity against invading pathogens, HEV infection with genotype 1 might dysregulate the balance and cause the adverse outcome. Furthermore, HEV infection with genotype 3 can be chronic in immunocompromised patients, with rapid progression, which has been a challenge since it was reported years ago. The virus has a complex interaction with the host cells in downregulating antiviral factors and recruiting elements to generate a conducive environment of replication. The virus-cell inte

Who reads Advances in Hepatitis E Virus Biology and Pathogenesis?

Author

Lin, Shaoli (author);Zhang, Yan-Jin (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)