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Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin by Yoko Ikoma; Hiroyuki Takuwa; Asuka Nishino; Jun Maeda; Kazunori Kawamura; Takayuki Obata; Ming-Rong Zhang; Makoto Higuchi; Tetsuya Suhara is a Medicine article available to read on EtoBox.
What is Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin about?
Objective Positron emission tomography (PET) has been used to investigate changes in the concentration of endogenous neurotransmitters. Recently, this technique has been applied to the imaging of serotonin 2A receptors using [ 18 F]altanserin. In these measurements, a reduction in binding potential (BP) suggests an increase in endogenous serotonin levels caused by pharmacological or cognitive stimulations, and the sensitivity of BP reduction depends on the characteristics of [ 18 F]altanserin. In this study, we evaluated an analytical method for estimating the changes in endogenous serotonin levels based on PET scans with [ 18 F]altanserin at baseline and stimulated states and validated it using simulations and small animal PET studies. Methods First, in the simulations, the time-activity curves at baseline and the stimulated states were generated using an extended compartment model including the competition for the receptors between the administered [ 18 F]altanserin and endogenous serotonin. In the stimulated state, the magnitude and onset of the endogenous serotonin elevation were altered to varying degrees. In these time-activity curves, BP was estimated using the simplified re
Who reads Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin?
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- Author
- Yoko Ikoma; Hiroyuki Takuwa; Asuka Nishino; Jun Maeda; Kazunori Kawamura; Takayuki Obata; Ming-Rong Zhang; Makoto Higuchi; Tetsuya Suhara
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)