Can I read Structural Phenotypes of Knee Osteoarthritis: Potential Clinical and Research Relevance on EtoBox?

Structural Phenotypes of Knee Osteoarthritis: Potential Clinical and Research Relevance by Frank W. Roemer; Mohamed Jarraya; Jamie E. Collins; C. Kent Kwoh; Daichi Hayashi; David J. Hunter; Ali Guermazi is a Medicine article available to read on EtoBox.

What is Structural Phenotypes of Knee Osteoarthritis: Potential Clinical and Research Relevance about?

A joint contains many different tissues that can exhibit pathological changes, providing many potential targets for treatment. Researchers are increasingly suggesting that osteoarthritis (OA) comprises several phenotypes or subpopulations. Consequently, a treatment for OA that targets only one pathophysiologic abnormality is unlikely to be similarly efficacious in preventing or delaying the progression of all the different phenotypes of structural OA. Five structural phenotypes have been proposed, namely the inflammatory, meniscus-cartilage, subchondral bone, and atrophic and hypertrophic phenotypes. The inflammatory phenotype is characterized by marked synovitis and/or joint effusion, while the meniscus-cartilage phenotype exhibits severe meniscal and cartilage damage. Large bone marrow lesions characterize the subchondral bone phenotype. The hypertrophic and atrophic OA phenotype are defined based on the presence large osteophytes or absence of any osteophytes, respectively, in the presence of concomitant cartilage damage. Limitations of the concept of structural phenotyping are that they are not mutually exclusive and that more than one phenotype may be present. It must be ackno

Who reads Structural Phenotypes of Knee Osteoarthritis: Potential Clinical and Research Relevance?

Author

Frank W. Roemer; Mohamed Jarraya; Jamie E. Collins; C. Kent Kwoh; Daichi Hayashi; David J. Hunter; Ali Guermazi

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)