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Longitudinal lipidomic analyses in patients undergoing therapeutic plasma exchange with albumin replacement as a treatment for Alzheimer’s disease by Carla Minguet; Ana Maria Ortiz; Ricardo Gonzalo; Raquel Horrillo; Laura Núñez; Agustin Ruiz; Oscar L. Lopez; Mercè Boada; Antonio Páez; Montserrat Costa is a Medicine article available to read on EtoBox.
What is Longitudinal lipidomic analyses in patients undergoing therapeutic plasma exchange with albumin replacement as a treatment for Alzheimer’s disease about?
Background: Differences in ceramides, glycerides, phospholipids, cholesterol esters and fatty acids (FA) lipid subclasses have been reported between Alzheimer's disease (AD) patients and healthy subjects (Liu et al. Transl Psychiatry 2021;11:344). The AMBAR phase 2b/3 trial is a therapeutic approach for mild-moderate AD patients (MMSE:18-26) based on a 14-month program comprising 18 plasma exchange procedures with albumin replacement (PE-Alb) to remove neurotoxic Aβ and other pathological substances from plasma, thus slowing AD progression (Boada et al. Alzheimers Dement 2020;16:1412). The aim of this study was to assess PE-Alb effects on lipidomics across the AMBAR study.
Who reads Longitudinal lipidomic analyses in patients undergoing therapeutic plasma exchange with albumin replacement as a treatment for Alzheimer’s disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Carla Minguet; Ana Maria Ortiz; Ricardo Gonzalo; Raquel Horrillo; Laura Núñez; Agustin Ruiz; Oscar L. Lopez; Mercè Boada; Antonio Páez; Montserrat Costa
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)